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Scientific Papers
"MS: Probable Cause and Best Bet Treatment" Dr. Ashton Embry © 1996
Section 7: Types of MS
One related area regarding MS pathogenesis is that of the outward manifestation of the disease. Most cases of MS start with a relapsing-remitting (RR) character which refers to short periods when new symptoms appear or old ones increase (attack or exacerbation) and long intervals when symptoms improve somewhat or stabilize (remissions). On average it would appear a typical case involves about one attack a year (Sibley, 1992). Notably it has been found through MRI studies that lesion forming activity occurs even during remissions (Lai et al., 1996). Thus in many cases it would appear as if disease activity is essentially continuous with a waxing and waning character.

In many instances RRMS evolves into secondary progressive (or chronic progressive) MS where there are no clear relapses and remissions, only gradual deterioration.

In some cases, MS does not present in a relapsing- remitting manner but rather gradual deterioration begins at onset. This type of MS is known as primary progressive MS.

If untreated, RRMS can have a highly variable course in terms of disabilities although an average rate of decline of one EDDS (a scale for assessing disability state) level every six years has been documented (Swank and Dugan, 1987; Sibley, 1992).

Any proposed cause of MS should be able to explain the various types of MS and the observed average decline rate.
End section 7.
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